Causes of Protein losing enteropathy

Means: Excessive loss of protein into the gut lumen, sufficient to cause hypoproteinaemia.

1. With mucosal erosion or ulceration
2. Without mucosal erosion or ulceration
3. With lymphatic obstruction

A. With mucosal erosion or ulceration
• Crohn’s disease
• Ulcerative colitis
• Radiation damage
• Oesophageal, gastric or colonic carcinoma
• Lymphoma
B. Without mucosal erosion or ulceration
• Tropical sprue
• Menetrier’s disease
• Bacterial over growth
• Coeliac disease
• Eosinophilic gastroenteritis
• SLE

3. With lymphatic obstruction
• Intestinal lymphangiactasia
• Constrictive pericarditis
• Lymphoma
• Whipple’s disease

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